You'll have to be more specific on what exactly you'd like to do. C, C++, RealBasic, php, perl, Objective-C and many other programming languages can connect to mySQL databases and each have the ability to create either a text-based GUI or a more robust GUI.
What programming languages are you familiar with? Would you like to develop a desktop-based application, or a web-based application? What kind of application are you looking to develop -- something to execute arbitrary queries on a mySQL database, or some kind of application that displays data based upon user-input form a mySQL database? What steps have you already taken in developing an application with mySQL integration?
FileMaker Pro can integrate easily with a mySQL database. Information on this was found easily with a simple 3-second Google search:
http://www.filemaker.com/support/tec...686F76B3C80C44