iSync uses Palm's HotSync Manager with a conduit. So basically, you should keep Palm Desktop with everything that belongs to it installed. You might not need the Palm Desktop application itself, but then again it doesn't come up automatically, either. Just forget about it after using iSync for the first time.
Mac user since 1987. Running Mac OS X 10.8 Mountain Lion on a MacBook Air 11" & an iMac 27" and whatever's newest for my iPhone 4s, iPad 3 and AppleTV 2.
Apple Certified System Administrator 10.6, Apple Sales Professional 2008-2011, Apple Certified Mac Technician.