I've used fink for a long time, and it has proved to be quite simple (especially if you use FinkCommander, although it's not necessary) and generally stable. The package selection is ever growing and fairly up to date. However, if you need something specific that is not offered with one distribution system, you can obviously try another.
Also, as far as I can tell, developers from both sites (among others) are working together over at
Metapkg, in order to provide joint releases, but I don't really know know too many details. They seem to have released "Gentoo MacOS", using the Portage package manager from Gentoo Linux, but you're gonna have to ask someone more in the know for anything coming on the horizon.