What data is going to be placed on this backup? I'm assuming if its being backed up, that you might find it vital?
Having gone through months of disaster recovery planning, depending on your usage and environment will dictate what they will find as acceptable for backup. Remember there is only one reason for backup and that is restoration. If you use a fairly non-mainstream media source now, what are your odds that you'll be able to find a replacement drive in 10 years to restore from, if need be, if you don't migrate that data off to a more mainstream media type.
For example, I looked at sait drives during my research, but decided to go with the more popular LTO2, not because the technology is better, or even more cost effective, but simply because more people are using it, which will make it easier to get support. Go back to VHS vs Beta and apply that argument to this one.
For the amount of data your trying to move, you can really use almost anything, which gives you tons of options. The idea of DLT or SDLT isn't a bad idea. I used SDLT for a long time and, again, its a widely used tape media. You do, then, have the cost of getting that data to the tape itself, as OS X doesn't have any built in tape drivers. For an environment of that size, I'd recommend BRU by Tolis Group. It scales pretty well and has some very nice command line tools. Licensing isn't very expensive and I would prefer it over a smaller, possibly cheaper alternative because of the support and stability of Tolis Group...you know they'll be around, in theory, longer than a unknown. You'll find that many drives actually ship with a BRU license, so that'll save you some cash right there!
If you want to read more about it, grab the documentation from my site. I have to update the BRU section, though. When I originally had to have the doc done, I wasn't able to get the new version of BRU to run with the new tape device I had just received. When I revisited it, that all changed and I'm backing up about 2TB with it on average.
My site's in my sig, just click on the Projects tab...the mirror should be faster to get the PDF, if you're interested.