I think all my applications are starting slower since the 10.2.1 update today. It seems that little arrow just throbs and throbs until it finally starts...
Apps like Testedit take about 15 bounces to start.
It seems that when you update from the command line it doesn't do any optimization, so I did an update_prebinding and it seemed to make a big difference...
You don't need to do it often (like, for example, defragmenting files) but I do it whenever I drag-and-drop install an application, or after major updates to the system (just in case Installer doens't do it completely).