Hanging stuff and the ball

First problem was when I go to the volume/keyboard bar top right I just get the spinning ball, and the clock doesn't change after startup. Entourage and Suitcases hang on startup, but are OK if I relaunch them. I've run disc utility from my startup disc, and it says everything's OK. If I run disc utility from my hard drive to repair permissions it just hangs without opening properly.
Any ideas gratefully received.
 
Thanks. Actually most of the problems cleared up when I trashed Extensis Suitcases, which I'd installed recently. A few things gave me a hunch this might be the trouble. However I'll zap the Pram anyway. Do you suggest this should be done regularly, or only when there's a problem (working on if it ain't broke, don't fix it).
 
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