I'd say defragging a drive is a bad idea. HFS+ (and Mac OS X) is designed to have a certain amount of disk fragmentation to protect against file fragmentation. Defrag utilities only care about making the drive
look good, your actual files it could care less about.
Yep, if you don't have problems now, defragging is as good a way as any to create some.
Oddly enough, over the past 6 years the only people I work with who have had file system issues have been those who (against my recommendations) defrag their drives. Could be a coincidence... and then again.