Cheryl and Doug, let me make sure I understand your info/advice:
Doug, I just did a Get Info on my HD, and sure enough, "System" was identified as the owner. Is that the "default" owner, or does it just look like that after a major install (of the OS or an app?)?
Cheryl, I clicked open the lock in the Get Info box (the same one I opened for Doug, above), and changed the owner from "System" to "Me". Is that what you mean by "running permissions"? How often should I do this? Or are you referring only to what Disk Utility's "Repair Permissions" does?
Backing up a bit here, Software Update is a wonderful tool, and so are things like Cocktail and MacJanitor (the latter of which, yes, I use at frequent and regular intervals), but it seems that there are many maintenance tasks or diagnostic/basic repair tasks that are easily overlooked: resetting PRAM, "running permissions", the CUDA key combo another contributor mentioned. It's a bit confusing to remember all these things when you run into trouble and are looking for, naturally, the quickest fix around your problem. Am I simply being lazy not having all this stuff in mind, or is there a 'one-stop-shop' (besides this forum?) that seems to rattle off all these potential factors in one document/resource/tool?