As many have said, for the most part, yes.
I'm running RedHat 8 on my (old, decrepid) Dell box, and there are some differences but for the most part I can find my way around in the shell.
If you're going to be doing simple things like running a server (www, ftp, nntp, smb, etc...) it's all pretty much the same, navigating the file system is for the most part the same. Apache's httpd.conf which is universal whether you're running it on Windows or RedHat...
And if you've used a particular piece of software (like pico, for example, which does not come in the default RedHat linux installation) you can almost always find a port to your version and just install it yourself--which is really handy.