Someone else's TiPB was have problems launching several apps had me look at it, I checked out MacOSX.com and found this thread
I re-installed iTunes 2 (2.0.1) on the TiPB, after the long optimization process, and restart, his system was acting completely normally.
I noticed while testing, that the apps failing to properly launch were limited to carbon apps, and they were listed in Top, and the process viewer
in top, each app that failed to launch would use about 900K of ram
all affected apps could not be quit, or force quit, this would even cause the computer to give an error message when you try to restart from the apple menu
the only solution to forcing it to restart was to use process viewer (or terminal) to force quit the window manager, which drops you to the login screen, where you can click on the restart button, which successfully for me, made the TiPB finally restart
thanks to the previous posters, for allowing me to do a quick and easy fix =)