You're going to have to provide a whole lot more information than that.
-What Mac?
-What operating system version (don't just say 9 or X, be specific as the the version, like 10.4.4 or 10.3.9 or 9.2.2)?
-What version of the applications in question?
-What did you do before these apps stopped working?
It's very hard to determine what's wrong without any details.