I know that you are talking about something slightly different, and that is "accessing an MS Access database stored on your local HD".
However, you could access it through an ODBC (bridge to bridge) connection to a surrounding windows machine. In this way, it may help solve your problem.
I don't remember seeing a binary port to mac OS X, but it should work using the free bsd stuff to compile it on the mac os x (I haven't tried this, so it might be a project in itself).
There is another open source project that is creating code that will read (and write) an access db directly on, potentially, any machine. I understand that it is working to some degree. http://sourceforge.net/projects/haccess/
you may want to look at it.
Personally, I have had tons of trouble with MS Access on windows machines. If possible, I'd recommend moving to almost any other db. I recognize that sometimes that is not possible.