As Cadre said, Wine only implements the API. The API is no use if your program is compiled for a completely different chip than the one in your computer - it runs only on Linux under x86, not any other architecture.
Any program that lets you run x86 binaries on a non-x86 architecture will have to be a full PC hardware emulator. If you want to pay money, this means Virtual PC. If you want to wait or become an open source developer and help port code, this means Bochs.
I don't know whether there is any work being done on Bochs for OS X, although it does apparently run under Classic Mac OS, as well as UNIX with X-Windows. Given that, it seems reasonable that there should before too too long be an OS X port.
http://www.guisoft-corp.com/bochs.htm