I have an Epson Perfection 1250. It's software is Classic-enabled (not native) but it works great. Installed it in Classic. When I turn the computer on (booting into OSX), the computer notes that a scanner is attached and readies it. Whenever I need to scan, I just press the button on the front and the software (from Classic) runs.
Works great!
I haven't gone to their website lately to see if they have OSX-native software out there (or pending). But so far, I don't really mind.