I upgraded to 10.3.6 via the software update not Mail and Safari are not responding - other apps do work.
I repaired permissions with Terminal
sudo diskutil repairpermissions /
Restarted with no luck...
Please help!!
It's still a good idea to try downloading and installing the Combined 10.3.6 updater (as it's been since at least 10.1.x) The combined updaters seem to 'repair' a lot of issues, especially if the system has been auto-updated a number of times.
You can get that updater HERE (it's about 92MB)