...it should be noted that any Windows virii/spyware that you get in VirtualPC will be limited to the VirtualPC operating system, and cannot, in any way, damage or affect your Mac OS X system. At the worst, your Virtual OS will be kaput and will have to be deleted and re-installed, but OS X and your hardware will be absolutely fine.
The virus can also attack any file that can be accessed from the VPC environment, and this can be your whole Mac if you open it to VPC. Of course the virus will not reproduce on MacOS, but it still can delete files.
Another "agonstic" virus type is made of the M$ Office macro viruses. These are based on Office and not on the underlying OS.
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